2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Dipeptidyl Peptidase

Dipeptidyl Peptidase

Peptidase

DPP

Dipeptidyl Peptidase

Related Products

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Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis. The dipeptidyl peptidase family, including DPP-IV DPP7, DPP8, DPP9, fibroblast activation protein and others, cleave the peptide bond after the penultimate proline residue and are drug target rich.

DPP-IV (DPP4 or CD26) is a serine protease detected on several immune cells and on epithelial cells of various organs. Besides the membrane-bound enzyme, a catalytically active soluble form is detected in several body fluids. Both variants cleave off dipeptides from the N-termini of various chemokines, neuropeptides, and hormones. DPP IV plays a key role in immune-regulation, inflammation, oxidative stress, cell adhesion, and apoptosis by targeting different substrates. DPP IV inhibitors are commonly used as hypoglycemic agents.

DPP8 and DPP9 show DPPIV-like activity and share a very high-sequence similarity to each other. DPP8 and DPP9 are intracellular N-terminal dipeptidyl peptidases (preferentially postproline) associated with pathophysiological roles in immune response and cancer biology.

Dipeptidyl Peptidase Isoform Specific Products:

Dipeptidyl Peptidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10284R
    Linagliptin (Standard)
    		Inhibitor
    Linagliptin (Standard) is the analytical standard of Linagliptin. This product is intended for research and analytical applications. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
    Linagliptin (Standard)
  • HY-10285S2
    Saxagliptin-13C2
    		Inhibitor
    Saxagliptin-13C2 (BMS-477118-13C2) is 13C labeled Saxagliptin. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research.
    Saxagliptin-<sup>13</sup>C<sub>2</sub>
  • HY-Z3637
    (–)-Sitagliptin carbamoyl glucuronide
    		Control
    (–)-Sitagliptin carbamoyl glucuronide is a minor metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor Sitagliptin (HY-13749).
    (–)-Sitagliptin carbamoyl glucuronide
  • HY-A0023AR
    Alogliptin (Standard)
    		Inhibitor
    Alogliptin (Standard) is the analytical standard of Alogliptin. This product is intended for research and analytical applications. Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes.
    Alogliptin (Standard)
  • HY-N4069
    Lupinalbin A
    		Inhibitor
    Lupinalbin A (Boeravinone L) is a dipeptidyl peptidase 4 (DPP4) and α-glucosidase inhibitor with IC50 values ​​of 45.2 and 53.4 µM, respectively. Lupinalbin A exhibits antidiabetic activity.
    Lupinalbin A
  • HY-14291S
    Vildagliptin-d3
    		Inhibitor
    Vildagliptin-d3 is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity[1][2].
    Vildagliptin-d<sub>3</sub>
  • HY-135534
    Lysine 4-nitroanilide
    Lysine 4-nitroanilide is an amino acid derivative of 4-nitroanilide (component C1 substrate) used in enzymology research and as a substrate for arylamidase/DPP-3 activity assays.
    Lysine 4-nitroanilide
  • HY-15981R
    Omarigliptin (Standard)
    		Inhibitor
    Omarigliptin (Standard) is the analytical standard of Omarigliptin. This product is intended for research and analytical applications. Omarigliptin (MK-3102) is a potent, selective, orally active and cross the blood-brain barrier dipeptidyl peptidase 4 (DPP-4) inhibitor. Omarigliptin shows anti-parkinsonian activity. Omarigliptin has the neuroprotective effect to improve diabetes-associated cognitive dysfunction.
    Omarigliptin (Standard)
  • HY-119266
    HTS13517
    		Inhibitor
    HTS13517 is a DPP4 inhibitor, with an IC50 of 10.73 μM.
    HTS13517
  • HY-13749BR
    Sitagliptin (phosphate monohydrate) (Standard)
    		Inhibitor
    Sitagliptin (phosphate monohydrate) (Standard) is the analytical standard of Sitagliptin (phosphate monohydrate). This product is intended for research and analytical applications. Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
    Sitagliptin (phosphate monohydrate) (Standard)
  • HY-10285R
    Saxagliptin (Standard)
    		Inhibitor
    Saxagliptin (Standard) is the analytical standard of Saxagliptin. This product is intended for research and analytical applications. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research.
    Saxagliptin (Standard)
  • HY-109060
    Garvagliptin
    		Inhibitor
    Garvagliptin (ZYDPLA1) is an orally active, competitive and long acting DPP4 Inhibitor, with an IC50 of 2.99 nM against human recombinant DPP IV. Garvagliptin (ZYDPLA1) exhibits antihyperglycemic effect.
    Garvagliptin
  • HY-10284S4
    Linagliptin-d5
    		Inhibitor
    Linagliptin-d5 (BI 1356-d5) is deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
    Linagliptin-d<sub>5</sub>
  • HY-U00346A
    TS-021
    		Inhibitor
    TS-021 is a selective，orally active，reversible and long-acting DPP-IV inhibitor，and exhibits significant inhibition selectivity against DPP-8 (> 600 fold)，DPP-9 (> 1200 fold) and other peptidases (> 15,000 fold). TS-021 inhibits DPP-IV activity in human plasma with an IC50 value of 5.34 nM. TS-021 has long-term persistent plasma drug concentration and potent antihyperglycemic activity，and increases in the active form of GLP-1.
    TS-021
  • HY-14291S5
    Vildagliptin-d6
    		Inhibitor
    Vildagliptin-d6 (LAF237-d6 ) is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.
    Vildagliptin-d<sub>6</sub>
  • HY-13749D
    (Rac)-Sitagliptin
    		Inhibitor
    (Rac)-Sitagliptin is an isoform of Sitagliptin (HY-13749), which is a potent and orally active inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
    (Rac)-Sitagliptin
  • HY-117985S
    Evogliptin-d9
    		Inhibitor
    Evogliptin-d9 (DA-1229-d9) is deuterium labeled Evogliptin. Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation.
    Evogliptin-d<sub>9</sub>
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Dipeptidyl Peptidase Isoform Comparison

DPP-1

DPP-2

DPP-4

DPP-8

DPP-9

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Please try each isoform separately.

Dipeptidyl Peptidase Inhibitors
Product NameDPP-1DPP-2DPP-4DPP-8DPP-9Purity    
Sitagliptin  
DPP-4
  99.75%
Talabostat mesylate  
DPP-4
  98.35%
Puromycin aminonucleoside 
DPP-2
   99.86%
Linagliptin  
DPP-4
  99.91%
Brensocatib
DPP-1
    99.88%
Sitagliptin phosphate  
DPP-4
  99.85%
Diprotin A  
DPP-4
  99.58%
Vildagliptin  
DPP-4
  99.93%
1G244  
DPP-4
  98.66%
Omarigliptin  
DPP-4
  99.96%
Saxagliptin  
DPP-4
  99.96%
Teneligliptin  
DPP-4
  99.79%
Sitagliptin phosphate monohydrate  
DPP-4
  99.49%
Alogliptin Benzoate  
DPP-4
  99.99%
Alogliptin  
DPP-4
  99.76%
Nateglinide  
DPP-4
  99.51%
Trelagliptin  
DPP-4
  99.54%
Teneligliptin hydrobromide  
DPP-4
  99.99%
Anagliptin  
DPP-4, IC50: 3.8 nM
DPP-8, IC50: 68 nM
DPP-9, IC50: 60 nM
99.91%
γ-Glu-Tyr  
DPP-4, IC50: 6.77 mM
  98.35%
K579  
DPP-4
  99.19%
Trelagliptin succinate  
DPP-4
  99.96%
Diprotin A TFA  
DPP-4
  99.62%
Evogliptin tartrate  
DPP-4
  99.71%
Saxagliptin hydrochloride  
DPP-4
  99.71%
TS-021 free base  
DPP-4
  99.29%
Gosogliptin  
DPP-4
  99.83%
Timosaponin A1  
DPP-4, IC50: 33.25 μM
  99.70%
Sitagliptin-d4 phosphate  
DPP-4
  99.48%
Retagliptin phosphate  
DPP-4
  99.89%
Sitagliptin fenilalanil  
DPP-4
  99.76%
Cofrogliptin  
DPP-4
  99.07%
Azaleatin  
DPP-4
  98.80%
Gemigliptin  
DPP-4
  
Vildagliptin dihydrate  
DPP-4
  
Talabostat  
DPP-4
  
Fotagliptin benzoate  
DPP-4, IC50: 22.7 nM
  99.19%
Alogliptin-d3  
DPP-4
  99.61%
NDMC101  
DPP-4
  99.91%
Saxagliptin hydrate  
DPP-4
  ≥99.0%
NZ-97  
DPP-4, IC50: 18 nM
DPP-8, IC50: 1258 nM
DPP-9, IC50: 561 nM
HAEGT  
DPP-4
  98.86%
Alogliptin-13C,d3  
DPP-4
  
Teneligliptin-d8  
DPP-4
  
Linagliptin-d4  
DPP-4
  99.62%
Prodipine hydrochloride  
DPP-4
  99.84%
Fotagliptin  
DPP-4, IC50: 2.27 nM
  
Anagliptin hydrochloride  
DPP-4, IC50: 3.8 nM
DPP-8, IC50: 68 nM
DPP-9, IC50: 60 nM
(S)-Sitagliptin phosphate  
DPP-4
  
PB01  
DPP-4, IC50: 15.66 nM
  
MPO-IN-6  
DPP-4, IC50: 31.02 μM
  
Vildagliptin-d7  
DPP-4
  
DPP-4/GPR119 modulator 1  
DPP-4
  
Linagliptin-13C,d3  
DPP-4
  
DPP-4-IN-3  
DPP-4
  
DPP-8/9 probe-1  
DPP-4, IC50: .44 μM ([1])
DPP-8, IC50: 210 nM ([1])
DPP-9, IC50: 15 nM ([1])
AMG-222  
DPP-4
  
DPP-4-IN-1  
DPP-4, IC50: 49 nM
  
DPP8/9-IN-1   
DPP-8, IC50: 14 nM
DPP-9, IC50: 298 nM
DPP-4-IN-10  
DPP-4
  
DPP-4-IN-11  
DPP-4, IC50: 2.75 μM
  
DPP-4-IN-2  
DPP-4, IC50: 79 nM
  
Carmegliptin  
DPP-4
  
DPP-4/GPR119 modulator 2  
DPP-4
  
Nateglinide-d5  
DPP-4
  ≥98.0%
Teneligliptin-d4  
DPP-4
  
P32/98 hemifumarate  
DPP-4, Ki: 130 nM
  
SGP8  
DPP-4
  
DPP-4-IN-12  
DPP-4, IC50: 2 nM
  
DPP-4-IN-8  
DPP-4, Ki: 0.96 μM
  
VAMP  
DPP-4, IC50: 1 μM
DPP-4, Kd: 6.89 μM
  
DPP-4-IN-15  
DPP-4, IC50: 8.24 μM
  
Epostatin 
DPP-2
   
H-Gly-Pro-Hyp-OH acetate  
DPP-4, IC50: 2.51 mM
  
Lupinalbin A  
DPP-4, IC50: 45.2 μM
  
Vildagliptin-d3  
DPP-4
  
HTS13517  
DPP-4, IC50: 10.73 μM
  
TS-021  
DPP-4